envelope proteins – Communicable Diseases Research

Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds

양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화

Article

Published on 2022-12-012022-09-11
Journal: Virulence
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제,

SARS-Arena: Sequence and Structure-Guided Selection of Conserved Peptides from SARS-related Coronaviruses for Novel Vaccine Development

SARS-Arena: 새로운 백신 개발을 위한 SARS 관련 코로나바이러스에서 보존된 펩티드의 서열 및 구조 유도 선택

Article

Published on 2022-07-122022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 변종, 치료법,

[키워드] 3D structure affected against SARS-CoV agent analysis approach can be used case study caused CD8 computational method Computational methods conserved contribute coronavirus COVID-19 disease cross-reactive database development envelope proteins help HLA HLA-Arena HLA-B7 Human human leukocyte antigen humoral Humoral response immune response less leukocyte mitigate MOST Multiple sequence alignment N protein Notebook novel nucleocapsid nucleocapsid protein pandemic peptide peptides pHLA scoring Practitioner practitioners Prevent Protein protein regions protein sequence protein sequence alignment protein sequences Proteins Region related viruses responsible SARS-CoV SARS-CoV viruses SARS-CoV-2 SARS-CoV-2 virus Selection selection pressure Sequence alignment Spike protein structural modeling. susceptible T-cell T-cells target the disease the N protein the SARS-CoV-2 virus the spike protein therapy Vaccine development Vaccines variants viral envelope protein viral strains viruses widespread
[DOI] 10.3389/fimmu.2022.931155 PMC 바로가기 [Article Type] Article

The histologic and molecular correlates of liver disease in fatal COVID-19 including with alcohol use disorder

알코올 사용 장애를 포함한 치명적인 COVID-19에서 간 질환의 조직학적 및 분자적 상관관계

Article

Published on 2022-04-012022-09-11
Journal: Annals of diagnostic pathology
[Category] 진단, 치료법,

[키워드] ACE2 ACE2 expression activated activated macrophages alcohol Alcohol Abuse Alcohol liver disease Cell Control COVID-19 disease disorder endocytosed envelope proteins evidenced experiment expression fatal COVID-19 greater hepatic hepatic disease hepatic stellate cell Hepatic stellate cells Hepatitis higher risk histologic histologic findings IL6 induce Inflammation injection liver Liver disease livers lobular inflammation Macrophage macrophages mice molecular nucleocapsid protein Patient positive Protein RNA robust SARS-CoV-2 spike protein SARS-CoV2 SARS-CoV2 infection severe COVID-19 severe liver disease significantly spike Spike protein spike protein. subunit the spike protein TNFα Viral viral spike protein western blots
[DOI] 10.1016/j.anndiagpath.2021.151881 PMC 바로가기 [Article Type] Article

Dominant CD8 + T Cell Nucleocapsid Targeting in SARS-CoV-2 Infection and Broad Spike Targeting From Vaccination

SARS-CoV-2 감염에서 우세한 CD8 + T 세포 뉴클레오캡시드 표적화 및 백신 접종으로 인한 광범위한 스파이크 표적화

Immunology

Published on 2022-02-222022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), MERS, SARS, 진단, 치료법,

[키워드] anti-SARS-CoV-2 Anti-spike Antibody Response Antibody responses assays average boost breadth CD8 CD8+ T cells Cellular immune response cellular immunity Coverage COVID-19 COVID-19 symptom COVID-19 vaccine demonstrated density dominant ELISpot assays envelope protein envelope proteins epitope Epitopes evaluated Evaluating flow cytometry greater IFN-γ IFN-γ ELISPOT IL-4 Inclusion magnitude nucleocapsid persistence predicted protective role Receptor binding domain Region regions response responses against SARS-CoV-2 SFC spike spot-forming cell spot-forming cells subset sustained T cell T cell response T cell responses T cells targeting Th1 vaccination Vaccine Viral viral infections while
[DOI] 10.3389/fimmu.2022.835830 PMC 바로가기 [Article Type] Immunology

Regulation of Hepatitis B Virus Virion Release and Envelopment Timing by Nucleocapsid and Envelope Interactions

Article

Published on 2022-01-122023-06-13
Journal: Journal of Virology
[Category] B형 간염, Fulltext,

[키워드] Capsid protein CCC DNA covalently closed circular DNA envelope proteins envelopment hepadnavirus Hepatitis B virus nucleocapsid maturation virion secretion.
[DOI] 10.1128/JVI.01305-21 PMC 바로가기

Entry Inhibitors of Hepatitis B and D Viruses

Review

Published on 2022-01-012023-06-09
Journal: Advances in experimental medicine and biology
[Category] B형 간염,

[키워드] entry inhibitors envelope proteins HBV Host receptor.
[DOI] 10.1007/978-981-16-8702-0_12 PMC 바로가기 [Article Type] Review

Hepatitis B virus envelope proteins can serve as therapeutic targets embedded in the host cell plasma membrane

Article

Published on 2021-12-012023-06-11
Journal: Cellular microbiology
[Category] B형 간염,

[키워드] antiviral therapy envelope proteins HBsAg plasma membrane. T-cell therapy
[DOI] 10.1111/cmi.13399 PMC 바로가기

ATP1B3 Restricts Hepatitis B Virus Replication Via Reducing the Expression of the Envelope Proteins

Article

Published on 2021-08-012023-06-12
Journal: Virologica Sinica
[Category] B형 간염, Fulltext,

[키워드] ATP1B3 envelope proteins Hepatitis B virus (HBV) Proteasome-dependent degradation.
[DOI] 10.1007/s12250-021-00346-2 PMC 바로가기

JAK-STAT Pathway Inhibition and their Implications in COVID-19 Therapy

JAK-STAT 경로 억제 및 COVID-19 치료에 미치는 영향

Review

Published on 2021-06-012022-09-11
Journal: Postgraduate medicine
[Category] 유전자 메커니즘, 치료법,

[키워드] 3CL pro activated Activation adverse effects B cell Baricitinib clinical trial contrary COVID-19 COVID-19 patients COVID-19 therapy cytokine cytokine receptor cytokine signaling Cytokine storm dendritic cell dendritic cells determine Disease progression disease severity Efficacy effort endothelial cells envelope protein envelope proteins excessive inflammation Host hosts immune response immune responses implicated incidence of COVID-19 increase Inflammation Inflammatory marker inflammatory markers Inflammatory mediators inhibition inhibitor inhibitors inhibitors. Jak Jak-STAT JAK/STAT JAK/STAT pathway JAK/STAT signaling janus Janus kinase Lymphocytes macrophages mechanism membrane molecular Monocytes natural killer cell Natural killer cells nucleocapsid nucleus Phosphorylation Pneumocytes progression promote protease Proteases Protein recruitment reduce Regulatory Authorities regulatory authority required ruxolitinib SARS-CoV-2 SARS-COV-2 infection severity signaling cascade signaling cascades STAT STATs structural protein structural proteins supported suppressor suppressors survival T cell the disease Therapeutic strategies therapeutic strategy Tofacitinib translate Trigger tyrosine
[DOI] 10.1080/00325481.2020.1855921 PMC 바로가기 [Article Type] Review

SARS-CoV-2 proteins regulate inflammatory, thrombotic and diabetic responses in human arterial fibroblasts

SARS-CoV-2 단백질은 인간 동맥 섬유아세포에서 염증, 혈전 및 당뇨병 반응을 조절합니다

Article

Published on 2021-06-012022-09-11
Journal: Clinical immunology (Orlando, Fla.)
[Category] SARS, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus cardiovascular Cell cellular response complement coronavirus COVID-19 determine Diabetic disease envelope proteins exposure to expression fibroblast ICAM-1 Incubation Inflammation Inflammatory Inflammatory response Interaction marker mechanism mechanisms nucleocapsid progression Proteins RAGE regulate response responses responsible SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly spike structural proteins Support thrombosis thrombosis. thrombotic tissue Tissue Factor up-regulated Vascular vascular disease
[DOI] 10.1016/j.clim.2021.108733 PMC 바로가기 [Article Type] Article